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The ReTraCol project investigates transcription-replication collisions (TRCs) that contribute to genome instability, particularly in cancer. By employing biochemical and cryo-electron microscopy techniques, the project aims to elucidate the molecular mechanisms of R-loop-dependent TRCs and their implications for geneti…
One of the sources of genome instability is the occurrence of transcription-replication collisions (TRCs).
These collisions occur when the replication machinery collides with the transcription complex due to the presence of obstacles in the DNA template, such as DNA-bound proteins or structures known as R-loops, which are three-stranded nucleic acid structures that inhibit the normal progression of both systems.
These R-loops are often formed during transcription, but their assembly is regulated…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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