CORDIS Project
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This project investigates the role of RET and GDNF ligands in lymphocyte function and differentiation during blood cell development. By employing genetic and molecular techniques, the research aims to clarify how these molecules influence immune responses and may have implications for understanding diseases linked to R…
There is growing evidence that molecules classically allocated to nervous system function, such as the neurotrophic factors, are produced by lymphocytes and can also regulate their function.
The neurotrophic family includes the GDNF ligands (GFLs), which signal through the RET tyrosine kinase receptor.
In humans, mutations of the proto-oncogene Ret have been linked to different diseases, such as cancer and Hirschsprung’s disease.
Interestingly, RET expression has been reported in lymphocytes but…
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
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