CORDIS Project
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This project explores the role of a specific ion channel in immune cell function and its potential as a target for treating autoimmune diseases. It combines biophysics and immunology to understand how magnesium transport affects immune responses.
Low systemic magnesium (Mg2+) levels exacerbate pro-inflammatory diseases, suggesting a putative role of Mg2+ transport in immune system homeostasis.
The Mg2+ and calcium (Ca2+) conducting transient receptor potential ion channel, TRPM7 has an indispensable, vital role in cellular physiology. TRPM7 regulates cellular and systemic Mg2+ homeostasis and is essential for immune cell differentiation, proliferation and survival.
However, little is known about underlying mechanisms or the physiologic r…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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