CORDIS Project
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This project aims to develop a new approach for targeting tumor blood vessels in prostate cancer by identifying specific genes expressed in tumor endothelial cells. Using Next Generation Sequencing, the project will prioritize gene targets for monoclonal antibody development and test their effectiveness in preclinical…
Angiostatic compounds have made their way into the daily clinical management of cancer, but their impact on patient survival is rather limited.
This is likely due to the fact that most current drugs are antagonists of tumor produced growth factors, a strategy expected to induce drug resistance. A better strategy would be to target the tumor vasculature directly.
Several markers of tumor endothelial cells have been described but most of them lack sufficient specificity.The applicant proposes to u…
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