CORDIS Project
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RESTART investigates the mechanisms of blood regeneration from hematopoietic stem and progenitor cells in humans. By employing advanced single-cell techniques, it aims to improve outcomes in stem cell transplants for pediatric patients.
How hematopoietic stem and progenitor cells (HSPCs) regenerate blood is a major unsolved question, frustrating their effective use for therapy.
Every year, >40.000 patients receive an HSPC transplantation (HSCT), as a last-resort therapy for various diseases, including leukemia.
However, ~40% of HSCT recipients die, due to poor outgrowth of the donor HSPCs, inflammatory complications or relapse.
There is an unmet need for strategies to predict and prevent these adverse outcomes.
In mice, single-…
PrinsesMaximaCentrumvoorKinderoncologie
PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
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