CORDIS Project
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This project investigates the role of cohesin, a protein complex, in DNA damage repair and replication stress recovery. By utilizing various scientific techniques, it aims to understand how cohesin mutations contribute to cancer development.
Cohesin, an evolutionary conserved ring-shaped protein complex that topologically entraps DNA, has crucial roles in many structural and functional aspects of chromosomes including sister chromatid cohesion, genome organization, gene transcription and DNA repair.
The importance of cohesin in the maintenance of genomic stability has been known for some time.
Cohesin facilitates double strand breaks repair by homologous recombination and promotes the restart of stalled replication forks by template…
UNIVERSIDAD DE SALAMANCA
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