CORDIS Project
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This project explores the fundamental principles of copying biological information using synthetic systems. By leveraging advances in thermodynamics and molecular simulation, it aims to create minimal synthetic copying systems that mimic biological processes.
Copying of information-bearing polymer templates is vital to life.
The central dogma of molecular biology describes how a sequence of nucleotides in DNA is copied into a sequence of nucleotides in a newly-assembled RNA polymer, and then into a sequence of amino acids in a protein.
These processes involve sophisticated machinery in extant organisms, but even the ribosome is bound by the same physical principles as simpler systems that must have operated in early life.
Despite the fundamental impo…
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