CORDIS Project
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This project investigates the role of ciliary tip proteins in cellular functions and their link to genetic disorders known as ciliopathies. It aims to characterize the CCDC66 protein's localization and function, which is crucial for understanding ciliary assembly and associated diseases.
Cilia are conserved microtubule-based organelles, which extend from the cell surface and have diverse motility and sensory functions, integrating developmentally important signalling pathways.
As such, defects in ciliary assembly and/or function can lead to developmental disorders and multi-systemic genetic diseases, termed ciliopathies.
The ciliary tip, a region between microtubule ends and the ciliary membrane, is implicated in cilium assembly, disassembly, signalling, and motility.
Few ciliar…
KOC UNIVERSITY
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