CORDIS Project
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This project investigates the ecological and genetic factors influencing antibiotic resistance in bacteria, particularly focusing on the costs associated with resistance and the potential for compensatory mutations. Using high-throughput experimental evolution, it aims to understand how these factors contribute to the…
The evolution of antibiotic resistance poses an important threat to human health and welfare.
Antibiotic resistance is accompanied by fitness costs that have been shown to play a key role in the spread of resistance.
These costs are variable, but the underlying ecological and genetic causes of this variation remain obscure.
Unfortunately, bacteria can adapt to the cost of resistance by compensatory mutations, and this permits resistance to be maintained in pathogen populations after antibiotics…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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