CORDIS Project
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This project investigates the genetic mechanisms behind antibiotic resistance in bacteria, focusing on how mutations can lead to reduced fitness costs. By studying Escherichia coli, the research aims to uncover interactions between resistance mutations to inform new treatment strategies against multi-resistant infectio…
Antibiotic resistance is a major threat to public health.
Bacteria can become resistant by acquiring genes that counteract the action of antibiotics or by mutation of their targets.
These targets are usually involved in essential processes and typically resistance mutations can impair bacterial growth in absence of antibiotics.
However, combination of certain mutated alleles can result in an alleviation of this cost, thus favouring the acquisition of multiple resistances.
This project aims to un…
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