CORDIS Project
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This project explores how to rejuvenate the supportive environment for blood stem cells in older patients undergoing chemotherapy. By targeting specific cellular pathways, it aims to enhance recovery from treatment-related damage, potentially improving survival and quality of life for elderly cancer patients.
Cancer is a disease of the elderly and chemotherapy remains the mainstay of treatment.
The benefits of chemotherapy include increased overall survival, improvement in quality of life, and palliation of symptoms.
However, older patients are more susceptible to specific toxicities of chemotherapy, like myelosuppression and life-threatening neutropenia.
Among the tissues strongly affected by chemotherapy, the bone marrow sinusoidal endothelial cells constitute the most important supportive niche fo…
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
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