CORDIS Project
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This project aims to improve the understanding of inherited cardiac arrhythmias by exploring the interaction of genetic mutations with resilience and trigger factors. It focuses on the IKs potassium channel to develop personalized treatment strategies for affected individuals.
Up to 30% of individuals with inherited cardiac arrhythmias such as Long QT syndrome are not protected from sudden cardiac death despite state-of-the-art treatment. A major hurdle for effective risk stratification and treatment of inherited cardiac arrhythmias is the poor correlation between genetic variant and clinical manifestations.
Affected individuals, who harbour the same arrhythmia-causative mutation, paradoxically display a spectrum of clinical phenotypes ranging from a lifelong asymptom…
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