CORDIS Project
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This project aims to develop a gene therapy product that uses adenoviral vectors to enhance ion channel expression, temporarily increasing heart rates in fetuses with congenital complete heart block. This approach seeks to improve outcomes for high-risk patients, potentially enabling permanent pacemaker implantation af…
Congenital heart block is the most commonly observed type of foetal bradycardia, occurring in one in 15.000 live births. A significant subset of foetuses develops towards congenital complete heart block (CCHB), i.e., complete failure of the electrical excitation wavefront to be conducted over the atrioventricular (AV) node. CCHB is the most severe and life-threatening cardiac arrhythmia in utero.
Current medicinal treatments cannot significantly alter the cause of CCHB and therapeutic attempts a…
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