CORDIS Project
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This project investigates the role of the TDP-43 protein in amyotrophic lateral sclerosis (ALS) using a nematode model. It aims to identify genetic suppressors of motor impairment and understand neuro-muscular interactions to inform future therapeutic research.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that progressively causes loss of neuronal and muscle function, for which there is no known cure.
Although the genetic causes of ALS vary, the cytoplasmic accumulation of the TDP-43 protein in neurons is highly consistent among patients.
Thus, TDP-43 is believed to be a point of convergence in the pathway responsible for ALS progression.
However, while many genetic and cellular mechanisms have been linked to ALS, there is still a lack of und…
UNIVERSITAIR MEDISCH CENTRUM GRONINGEN
ACADEMISCH ZIEKENHUIS GRONINGEN
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