CORDIS Project
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This project investigates the reprogramming of somatic cells into pluripotent stem-like cells, focusing on the role of the Wnt/beta-catenin signaling pathway. It aims to understand the molecular mechanisms behind this process and its potential for organ regeneration in higher vertebrates.
Differentiation from zygotes in all cells of the body has been considered a unidirectional route.
Recently, however, it has become clear that the inverse path is possible, as the reprogramming of somatic nuclei, i.e. the de-differentiation of somatic cells in pluripotent stem-like cells.
To date, reprogramming has been induced in vitro by transferring somatic nuclei into enucleated oocytes, by fusing embryonic stem (ES) cells with somatic cells, and by transferring specific ES-factors into diffe…
FUNDACIO CENTRE DE REGULACIO GENOMICA
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Italy, Roma
Type: Research institute
Activity type: Research Organisations
SME: No
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