CORDIS Project
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This project investigates how DNA replication forks are stabilized during transcription in yeast. It aims to identify mechanisms that control fork stability and understand how these processes prevent genome instability, which is crucial for cancer research.
Genome stability during chromosome replication can be challenged by drugs affecting fork progression and intra-S DNA damage.
While the mechanisms preserving the integrity of replicating chromosomes in response to replication stress induced by exogenous genotoxic events have been widely studied (Branzei and Foiani 2005;
Branzei and Foiani 2007), those controlling fork stability under unperturbed conditions are less understood.
Specialized networks control the collision between replication forks a…
IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
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