CORDIS Project
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This project investigates how vertebrate eggs can reprogram somatic nuclei to create cloned organisms, focusing on overcoming epigenetic barriers. It aims to identify molecules in eggs that facilitate successful reprogramming and improve strategies for cell fate conversion.
Vertebrate eggs can induce the reprogramming of transplanted somatic nuclei to enable the generation of all cell types of a cloned organism.
However, the efficiency of nuclear reprogramming is low, and only a small proportion of the nuclear transfer embryos generated from differentiated cells reach a reproductive adulthood.
How the egg achieves the erasure of the previous somatic cell identity and the establishment of totipotency only in some instances remains a question of fundamental importanc…
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
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