CORDIS Project
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This project aims to develop techniques for directly converting somatic cells into specific cell types for regenerative medicine. By studying the mechanisms that restrict this conversion in a model organism, it seeks to enhance the efficiency of cell fate reprogramming.
Cellular replacement therapies for treating degenerative diseases such as Alzheimer’s will require the generation of lost tissues by reprogramming cell types.
While one strategy is to de-differentiate somatic cells into induced pluripotent stem cells with subsequent re-differentiation, an alternative strategy is to directly convert cells to the target cell type by using specific Transcription Factors (TFs).
The latter strategy utilizes TFs that can induce specific cell fates; however, their abil…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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