CORDIS Project
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This project explores the early events of epigenetic reprogramming, focusing on DNA demethylation and chromatin changes during mouse development. It aims to identify key factors and repair mechanisms involved in these processes, enhancing our understanding of cell fate manipulation in laboratory settings.
Epigenetic reprogramming is a developmental process involving both genome-wide DNA demethylation and chromatin remodelling.
Under physiological conditions it occurs at distinct stages of normal embryonic development.
However, under in vitro conditions induction of this process can restore pluripotency in somatic cells, and in aberrant situations a similar dedifferentiation process can initiate carcinogenesis.
While the kinetics of the reprogramming that occurs in the course of normal developmen…
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