CORDIS Project
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This project investigates the mechanisms of DNA replication in human cells, particularly how oncogenes affect replication origins and genomic stability. It aims to map replication origins and understand the interplay between transcription and DNA replication to prevent replication stress.
Replication of the genome is of critical importance for cell proliferation and organismal development.
To ensure accurate and complete replication of their genome, eukaryotes have hundreds to thousands of replication origins.
In budding yeast, the genomic positions of all the origins are known, as is the order in which they fire.
In contrast, in human cells, the mapping of origins is controversial and origin firing may be stochastic and plastic.
Furthermore, while normal cells replicate their ge…
UNIVERSITE DE GENEVE
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