CORDIS Project
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This project investigates the process of DNA replication and its coupling with chromatin dynamics. By employing advanced biophysical techniques, it aims to elucidate the mechanisms of nucleosome assembly and their implications for epigenetic inheritance and cancer.
DNA replication is essential to cellular function.
During a lifetime, each of us synthesizes a light-year’s length of DNA, but this process is so robust that few of us will develop cancer.
In eukaryotes, DNA is packed into chromatin, a hierarchical DNA-protein assembly of which the nucleosome forms the basic unit.
Chromatin replication convolves DNA replication with the duplication and reassembly of all DNA-associated proteins.
Understanding the coupling between these processes has fundamental i…
TECHNISCHE UNIVERSITEIT DELFT
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