CORDIS Project
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This project investigates how chromatin organization affects genome function during DNA replication. By tracking histone variants, it aims to understand their dynamics and the impact of chromatin structure on epigenetic inheritance.
Within the nucleus of eukaryotic cells, chromatin organization has emerged to be a major regulator of genome function.
The question of how chromatin is shaped and maintained through DNA replication is key to understanding its impact.
Distinct histone variants, modifications and binding partners are linked to specific structural and functional domains and might constitute a stable epigenetic signature.
However, the passage of the replication fork disrupts parental nucleosomes and challenges exist…
INSTITUT CURIE
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