CORDIS Project
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This project explores the competition between Polycomb and Trithorax group proteins in gene regulation during development. It aims to understand how transient nucleosomes at Polycomb Response Elements influence gene expression and chromatin organization.
Polycomb group (PcG) and Trithorax group (TrxG) proteins are essential for maintaining different cell identities through chromatin-based regulation of gene expression during development. A crucial aspect of this system is the competition of PcG and TrxG proteins for cis-regulatory DNA elements called Polycomb Response Elements (PREs).
However, the mechanisms underlying this competition remain largely unknown.
Recent studies have shown that PREs are nucleosome-depleted sites, as a result of high…
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