CORDIS Project
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This project investigates how DNA replication affects chromatin organization and cellular identity. By studying pluripotent cells, the research aims to uncover the mechanisms behind epigenetic reconfiguration during cell fate transitions using advanced proteomics techniques.
All cells in our body share the same genetic information.
Cellular identity is determined by epigenetic mechanisms, which control gene expression.
Replicating cells should accurately replicate their DNA sequence and copy their epigenetic profile to maintain their identity. DNA replication entails the disruption of the chromatin organization ahead of the replication fork and its restoration behind it.
When cells change their identity in either normal development or abnormal processes as cancer, t…
KOBENHAVNS UNIVERSITET
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