CORDIS Project
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This project aims to understand how DNA replication is affected by various perturbations, which can lead to genomic instability. It develops techniques to study these disruptions, with implications for cancer and aging research.
Challenges to the stable maintenance of the human genome can come from both endogenous and exogenoussources.
However, one of the major threats to genome stability occurs during normal DNA metabolism.
Thegenome is particularly susceptible to perturbation during the S-phase of the cell cycle when DNA replicationoccurs.
This is because DNA replication forks can encounter chemical adducts, DNA secondary structures,topological constraints or bound proteins that hinder their progression.
In actively p…
KOBENHAVNS UNIVERSITET
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