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The ReMyelin project investigates the mechanisms behind ineffective remyelination in chronic Multiple Sclerosis lesions. By studying both intrinsic and extrinsic factors affecting myelin sheath formation, the project aims to identify ways to enhance remyelination, which is crucial for restoring nerve function and reduc…
The failure of the endogenous regenerative process – remyelination - in chronic Multiple Sclerosis (MS) lesions leaves axons denuded of myelin and contributes to the neurodegeneration that underlies the progressive disability associated with the disease.
Stimulating effective remyelination is therefore a key goal for regenerative medicine.
Neuropathological studies in humans and animal models have shown that remyelination results in short, thin myelin sheaths. predicted to be less efficient at a…
THE UNIVERSITY OF EDINBURGH
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