CORDIS Project
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This project investigates how DNA is accessed within nucleosomes during cellular processes like transcription and replication. Using advanced imaging techniques, it aims to reveal the molecular mechanisms of nucleosome remodeling, which is crucial for understanding chromatin dynamics in living cells.
In eukaryotic cells the DNA is packaged into nucleosomes and higher order structures which lead to a condensation and protection of the DNA.
During important cellular processes such as transcription or replication access to the DNA has to be granted.
This is facilitated by ATP dependent nucleosome remodelling.
The mechanistic details how the involved remodelling complexes succeed in providing access to the nucleosomal DNA are currently in spite of large experimental efforts not well understood.…
UNIVERSITAET ULM
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Germany, MUNCHEN
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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