CORDIS Project
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This project investigates how memory T cells utilize three-dimensional chromatin structures to enhance their response to pathogens and tumors. By employing advanced genomic techniques and CRISPR technology, it aims to uncover the molecular mechanisms that govern immunological memory and T cell activation.
T lymphocytes are essential for immunity to pathogens and malignancies.
Activated T cells can retain a memory imprint of their adversary (e.g. a virus), enabling them to respond more rapidly and vigorously to any subsequent encounters.
While memory T cell formation is critical for successful vaccination and anti-tumor immunity, dysfunctional memory T cells are a common feature of human disease, including allergy, autoimmunity and cancer. T cell activation emerges from changes in gene expression…
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
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