CORDIS Project
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This project studies the CRISPR-Cas immune system in microbes, focusing on how they adapt to viral threats. It aims to uncover mechanisms of memory formation against mutated invaders and explore potential applications for enhancing viral therapies against antibiotic-resistant infections.
Microbes in natural ecosystems are under constant evolutionary pressure from viruses.
To survive in this hostile environment microbes have evolved an adaptive immune system called CRISPR-Cas.
The immune system is based on incorporation of invader DNA sequences in a memory locus (CRISPR), the formation of guide RNAs from this locus, and the degradation of invading target DNA using CRISPR RNA-guided protein complexes.
Invaders escape immunity by making point mutations in the targeted region of the…
TECHNISCHE UNIVERSITEIT DELFT
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Netherlands, Wageningen
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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