CORDIS Project
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This project explores the role of macrophages in heart recovery after myocardial infarction in type-2 diabetes patients. It aims to uncover the mechanisms of impaired cytokine secretion and develop new therapeutic strategies to enhance recovery and prevent further cardiac events.
Type-2 diabetes (T2D) is a chronic condition strongly associated with cardiovascular diseases, mainly recurrent myocardial infarctions (MI), and generating enormous healthcare cost.
Macrophages orchestrate the remodelling of the heart post-MI by efferocytosis-mediated cytokine secretion.
Specifically, Mertk-mediated efferocytosis promotes vessel formation, tissue reperfusion and resolution of the inflammatory response via the secretion of the anti-inflammatory cytokines interleukin-10 (IL-10) an…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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