CORDIS Project
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This project explores the role of hormone-sensitive lipase in brain lipid metabolism and its implications for neuronal function. By studying its regulation in neurons, the research aims to enhance understanding of lipid signaling and its impact on brain health.
Several lipids and lipid-derived molecules play crucial roles in regulating brain function, affecting synaptic activity and plasticity, cerebral blood flow regulation, and neuroinflammatory processes.
Outside of the central nervous system, the hormone-sensitive lipase (HSL) mediates the actions of catecholamines, glucagon, and insulin on lipolysis.
While HSL is present in the brain, its role in brain lipid metabolism remains unknown.
Recent findings from the host lab demonstrate that HSL is abun…
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