CORDIS Project
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This project aims to develop a novel drug screening platform using human induced pluripotent stem cells to create cholangiocytes for modeling genetic disorders like Cystic Fibrosis. The goal is to produce functional cholangiocytes for therapeutic testing and research.
Intra- hepatic Cholangiocytes represent one of the main cell type of the liver with hepatocytes.
They line the biliary tract and fulfill essential functions such as bile modification and transport.
Cholangiocytes are targeted by a diversity of diseases including genetic disorders such as Cystic Fibrosis.
There is currently no cure for disorders affecting cholangiocytes and end stage disease require liver transplantation.
Importantly, primary cholangiocytes obtained from biopsy can not be grown i…
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