CORDIS Project
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This project investigates the regulation of mammalian developmental genes through long-range interactions and chromatin organization. Using mouse models, it aims to understand how these regulatory domains function and their evolutionary significance, particularly in relation to genetic syndromes in humans.
The aim of this grant is to understand how mammalian developmental genes, which are usually pleiotropic, are controlled via long-range regulations and how chromatin partitions into large and discrete regulatory domains, generally matching Topologically Associating Domains (TADs).
We want to understand how such domains emerged in evolution, how they are built during development and how they help implement enhancer functions.
We will use a large genomic interval in mouse chromosome 2 containing th…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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