CORDIS Project
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This project investigates the molecular mechanisms that regulate protein synthesis in cells, particularly in brain cancer. It aims to uncover how specific genes are expressed through translational control, which could lead to new therapeutic strategies.
The overall rate of protein synthesis is an important factor modulating cell and tissue metabolism.
In addition, the translational machinery plays key roles in controlling gene-specific expression in eukaryotic cells.
The regulatory mechanisms involve changes in the activities of components of translational complexes that lead to selective translation of specific subsets of messenger RNAs.
Modulations of translational activity are primarily mediated by changes in the phosphorylation states of tr…
Novartis Forschungsstiftung
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