CORDIS Project
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This project investigates the immune response in the intestine, focusing on the role of CD4 T cells in inflammatory bowel disease. It aims to uncover the signals that lead to pathogenic T cell differentiation, potentially revealing new therapeutic targets for conditions like Crohn's disease and ulcerative colitis.
Immune response in the intestine are tightly regulated to ensure host protective immunity in the absence of immune pathology. A permanent disturbance of this delicate balance can lead to the development of inflammatory bowel disease (IBD) comprising Crohn’s disease (CD) and ulcerative colitis (UC).
The aetiology of IBD is unknown, but it is thought to involve a complex interplay among genetic, environmental, microbial and immune factors.
Dysregulated effector CD4 T cell responses can be causativ…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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