CORDIS Project
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This project investigates how a specific integrin in dendritic cells activates a key immune regulator, transforming growth factor-beta, to control intestinal inflammation. It aims to understand the mechanisms behind this process and its implications for inflammatory bowel diseases.
Transforming growth factor-beta (TGF-b) plays a critical role in maintaining gut immune homeostasis.
Although ubiquitously expressed, TGF-b must be activated in order to enable subsequent signaling. TGF-b activation thus represents a major point of regulation of intestinal immune responses.I have shown that expression of alpha-v-beta-8 integrin (avb8) by dendritic cells (DCs) is required to activate TGF-b so that it can signal to T cells.
Furthermore, I have shown that avb8 expression is restric…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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