CORDIS Project
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This project focuses on understanding the molecular mechanisms of cardiac hypertrophy and its progression to heart failure. It specifically investigates the role of Muscle RING finger proteins in protein degradation, aiming to identify potential therapeutic targets to prevent heart failure.
Heart failure caused by cardiac hypertrophy is a growing epidemic and remains the most frequent cause of hospitalization in elderly patients in the European Union.
However, molecular mechanisms leading to cardiac hypertrophy and its transition into heart failure are poorly understood.
Maintenance of cardiac structure and function requires a precise control of protein synthesis and degradation; abnormalities in these processes can give rise to myopathies.
The protein degrading ubiquitin proteasom…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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