CORDIS Project
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This project investigates the regulation of RNA polymerase II, a key enzyme in gene transcription, by examining its assembly, transport, and the role of RNA-binding proteins in its mRNA turnover. The research aims to enhance understanding of transcription recovery after DNA damage and its implications for cancer treatm…
Cellular diversity in eukaryotic organisms is obtained through differential regulation of transcription, which is therefore a heavily studied step in gene expression.
Protein-coding genes are transcribed by RNA polymerase II (RNAPII), an enzyme consisting of twelve subunits.
Recently, work from my host lab, the Svejstrup lab, has suggested that depleting the number of fully assembled RNAPII molecules in the cell, through degradation of its main catalytic subunit RPB1, is crucial for achieving tr…
KOBENHAVNS UNIVERSITET
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