CORDIS Project
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This project investigates how SUMO modification influences the organization of the genome and nuclear processes such as DNA transcription and repair in yeast. By studying the yeast Saccharomyces cerevisiae, the project aims to clarify the role of sumoylation in regulating nuclear dynamics.
The organisation of the genome into separate domains and sub-compartments through higher order chromatin structure is an important means by which eukaryotic cells control nuclear processes such as DNA transcription and repair.
Recent evidence has implicated sumoylation as an important regulator of global nuclear architecture as well as allied processes such as telomere maintenance and DNA damage repair.
Using the yeast Saccharomyces cerevisiae as a model organism to look at nuclear dynamics in v…
Novartis Forschungsstiftung
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