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REGULADOSIX investigates the evolutionary and functional significance of X-chromosome inactivation in mammals. The project focuses on understanding gene dosage compensation mechanisms and their implications for development and disease using advanced genomic technologies and genetic engineering in mouse models.
Differences in gene dosage can be as powerful as to drive species evolution (e.g., whole-genome duplications) and as harmful as to lead to human diseases (e.g., aneuploidies or haploinsufficiencies).
Regulating the effects of gene-dosage differences is thus extremely critical, and this is paradigmatically illustrated by what happens to the X chromosome in mammals.
In XX individuals, one of the X chromosomes is transcriptionally silenced as a result of a developmental and epigenetic process calle…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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France, TOULOUSE
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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