CORDIS Project
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This project focuses on understanding the regulation of gene transcription by studying RNA Polymerase dynamics and interactions with protein factors and non-coding RNAs. It employs biochemical and structural techniques to uncover mechanisms affecting transcription regulation.
During the first step of gene expression, RNA Polymerase (RNAP) transcribes RNA from a DNA template in every living cell.
Crystal structures of RNAP core as well as RNAP elongation complexes (ECs) have revolutionized our understanding of transcription.
This groundwork paved the way for more complex questions addressing the regulation of transcription.
Because of its fundamental role, transcriptional regulation has an impact on every aspect of biology including a growing list of human diseases. T…
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
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