CORDIS Project
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This project explores the interactions between natural killer cells and HLA-DP molecules, revealing a new regulatory role for HLA-II in immune responses. The research aims to leverage these interactions for developing immunotherapies against infections and inflammatory diseases.
The human immune system has evolved sophisticated mechanisms to recognize and eliminate infected, stressed or cancer cells.
Presentation of antigens by HLA-I enables the identification of diseased cells by antigen-specific T cells, while changes in HLA-I expression levels are sensed by NK cells.
Many human NK cell receptors bind HLA-I; but whether and how NK cells might interact with HLA-II remained unknown.
We recently discovered that a subset of commonly expressed HLA-DP molecules serve as lig…
LEIBNIZ-INSTITUT FUR VIROLOGIE
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