CORDIS Project
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This project explores kidney regeneration by studying the ability of neonatal mice to generate new nephrons. It aims to identify molecular drivers of this process and develop kidney cell populations for therapeutic applications, addressing genetic kidney disorders.
Kidney non-endocrine functions are primarily performed by millions of individual integral units called nephrons.
Although the adults of simple vertebrates (fish, amphibians and reptiles) have the ability to regenerate entire nephrons by a process called “nephron neogenesis”, this capacity is absent in birds and mammals.
In this regard we have observed, for the first time, that the murine neonatal kidney is able to generate new nephrons after the resection of the 20 per cent of the kidney mass. I…
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
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