CORDIS Project
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This project investigates the genetic basis of human adaptation by focusing on regulatory regions of DNA, particularly cis-regulatory elements. It employs innovative techniques like hybrid cells and massively parallel reporter assays to map gene expression changes and understand their impact on human evolution and heal…
While the phenotypes that set us apart from our closest extinct and extant relatives have been largely demarcated, we are still far from understanding the genetics of human adaptation, and how these changes affect our current anatomy, physiology, and health.
Most human adaptations have likely occurred in regulatory regions, particularly in cis-regulatory elements, such as promoters and enhancers.
However, our ability to study cis-regulatory evolution is limited due to the complexity of identifyi…
WEIZMANN INSTITUTE OF SCIENCE
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