CORDIS Project
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This project investigates the regulation of the AIP gene, linked to pituitary tumors, to understand its role in tumor development. It explores transcription factors, microRNA interactions, and genetic variants to uncover mechanisms that influence tumorigenesis.
Background:
Pituitary adenomas are a public health problem, due to their prevalence, morbidity and medical costs. AIP is a tumor suppressor gene that was recently linked to pituitary tumors in up to 30% of the familial isolated pituitary adenoma syndrome (FIPA) families, an autosomal dominant disease with incomplete penetrance. AIP mutation-positive patients are younger (children/young adults), have more aggressive disease, and respond less well to treatment than non-mutated patients.
The mechan…
QUEEN MARY UNIVERSITY OF LONDON
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