CORDIS Project
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This project investigates the role of non-canonical Wnt signaling pathways in regulating the redox state of the heart, particularly in the context of obesity. It combines clinical studies with laboratory experiments to identify potential biomarkers and therapeutic targets for heart diseases.
Myocardial redox signalling is a critical regulator of myocardial physiology and a therapeutic target in cardiovascular science, while obesity seems to trigger myocardial oxidative stress.
The non-canonical wnt signalling pathways (Ca2+-dependent (CDP) and planar cell polarity pathway (PCP)) are important in cardiac development and they are also involved in obesity (wnt ligands are involved in adipose tissue expansion), although their role in the adult myocardium is unknown.
We propose to define…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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