CORDIS Project
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The REDAVIP project investigates how herpes simplex virus-1 affects host DNA nucleases, aiming to restore their antiviral function. By understanding the interaction between viral proteins and nucleases, the project seeks to identify drugs that can enhance the body's ability to clear herpesvirus DNA, potentially leading…
Every individual carries at least a herpesvirus causing mild to serious diseases without definitive cure.
Although in theory, herpesvirus genomes can be degraded by host DNA nucleases (DNASEs), the ER preliminary data has evidenced DNASE2B protein levels to decrease upon herpes simplex virus-1 (HSV-1) infection.
In order to restore DNASEs anti-viral potential, REDAVIP aims to 1) uncover the susceptibility of DNASEs to HSV-1, 2) gain mechanistic insights of HSV-1 proteins and DNASEs interaction,…
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
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