CORDIS Project
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This project investigates DNA replication mechanisms in the Leishmania parasite, focusing on the role of origin-independent replication driven by recombination. It aims to understand how this process contributes to genome adaptability and drug resistance.
In any organism, the need to reproduce is paramount, with genome replication being the earliest step in the process.
The machinery and mechanisms of DNA replication are widely conserved, with initiation occurring at defined bi-directional DNA synthesis sites termed origins.
Though origins may not be conserved DNA sequences, they are defined through binding conserved replication initiator factors.
In some circumstances, such as after DNA damage or origin deletion, origin-independent replication c…
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