CORDIS Project
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This project investigates the formation of lipid droplets, which are essential for cellular metabolism, using advanced imaging techniques. By employing cryo-correlative light and electron microscopy, it aims to create detailed 3D models of lipid droplet biogenesis in human cells, revealing the molecular machinery invol…
Lipid droplets (LDs) are neutral lipid (NL) storage organelles, central for cellular metabolism.
Current models of LD biogenesis postulate that synthesis of NLs in the ER bilayer favors their phase separation, followed by bending of the bilayer and budding of the LD into the cytoplasm, coordinated by a specific, not fully characterized, molecular machinery.
Understanding of LD biogenesis through direct observations at molecular resolution is critically lacking. A major obstacle is that conventio…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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