CORDIS Project
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This project investigates how herpes simplex virus DNA activates the innate immune response in human cells. By exploring the mechanisms of DNA release and recognition, it aims to identify potential new drug targets and improve vaccine strategies.
Herpes simplex virus 1 and 2 (HSV1/2) are important human pathogens, causing both acute and recurrent infections leading to serious diseases such as encephalitis, herpes keratitis, genital herpes, and potentially fatal disseminated disease in newborns.
Pathogen recognition by the innate immune system is mediated via host-encoded pattern recognition receptors, which recognize conserved pathogen-associated molecular patterns (PAMPs) and trigger the production of pro-inflammatory cytokines and chem…
AARHUS UNIVERSITET
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